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Cancer melanoma research

Trusted Antibodies & Reagents for Precision Research

For 25 years, Cell Signaling Technology has delivered validated, high-performance tools for cancer, immunology, neuroscience, and drug discovery.

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Industry-Leading Validation Across Key Applications

Western Blot

IHC

Flow Cytometry

ChIP

ELISA

Proteomics

Multiplex IHC

CUT&RUN/Tag

For 25 Years, Trusted by Researchers Worldwide

Cell Signaling Technology (CST) is a leading provider of research antibodies, reagents, and kits for life science research. Our mission is to accelerate discovery by providing high-quality, application-validated tools that empower scientists in academia and industry.

With over 16,000 products rigorously validated across multiple applications, CST supports research in cancer, immunology, neuroscience, metabolism, and drug development. Our commitment to transparency, reproducibility, and scientific excellence has made us a trusted partner in laboratories around the globe.

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Cell death pathway illustration

Featured Research Products

Application-validated tools for precision biology

Phospho-Akt (Ser473)

Phospho-Akt (Ser473) (D9E) Rabbit mAb

Cat. #4060 | WB, IHC, IF, F, IP

Key regulator in PI3K/Akt signaling pathway. Validated in human, mouse, rat.

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PD-L1 antibody

PD-L1 (E1L3N) Rabbit mAb

Cat. #13684 | IHC, WB, IF, F

Critical immune checkpoint protein. Widely used in immuno-oncology research.

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Phospho-p44/42 MAPK

Phospho-p44/42 MAPK (Erk1/2) (T202/Y204)

Cat. #4370 | WB, IHC, IF, F, ELISA

Detects activated ERK1/2 in multiple species. Essential for signal transduction studies.

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ROS1 antibody

ROS1 (D4D6) Rabbit mAb

Cat. #3287 | WB, IHC, IF

Oncogenic receptor tyrosine kinase. Used in cancer and targeted therapy research.

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HA-Tag antibody

HA-Tag (C29F4) Rabbit mAb

Cat. #3724 | WB, IHC, IF, IP, F

High-affinity antibody for detecting HA-tagged recombinant proteins.

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GAPDH antibody

GAPDH (14C10) Rabbit mAb

Cat. #2118 | WB, IHC, IF, F

Reliable loading control for Western blotting and immunodetection.

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Cleaved Caspase-3

Cleaved Caspase-3 (Asp175) (5A1E) Rabbit mAb

Cat. #9664 | WB, IHC, IF, F

Specific marker of apoptosis. Detects endogenous levels of cleaved caspase-3.

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NF-kappaB p65

NF-kappaB p65 (D14E12) Rabbit mAb

Cat. #8242 | WB, IHC, IF, ChIP, F

Transcription factor involved in inflammation, immunity, and cell survival.

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Research Areas We Support

Cancer Research

From oncogenes to tumor suppressors, our tools support discovery in melanoma, breast, lung, and other cancers.

Immunology & Immuno-Oncology

Immune checkpoints, T-cell activation, cytokine signaling, and tumor microenvironment analysis.

Neuroscience

Neurodegeneration, synaptic plasticity, neuroinflammation, and neural development pathways.

Metabolism

Insulin signaling, AMPK pathway, mitochondrial function, and metabolic disease research.

Epigenetics

Histone modifications, chromatin remodeling, DNA methylation, and gene regulation.

Drug Discovery & Development

Target validation, mechanism of action, biomarker discovery, and preclinical studies.

Custom Services & Support

Custom Antibody & Reagent Solutions

  • Carrier-free custom antibody formulations
  • AQUA and custom blocking peptides
  • Custom conjugation service (fluorescent, biotin, etc.)
  • Bulk quantities and lot reservations
  • Proteomics analytical services
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Technical Support & Resources

  • Expert technical support team
  • Detailed protocols and troubleshooting guides
  • PhosphoSitePlus® PTM database
  • Pathway diagrams and scientific webinars
  • Publications and research posters
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Get in Touch

For product inquiries, technical support, or custom service requests, visit the official Cell Signaling Technology website.

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